COLUMBUS (WCMH) — Republican Josh Mandel announced Wednesday that he will run for U.S. Senate in 2022.

The seat is being vacated by Republican Senator Rob Portman, who announced in January he would not run for re-election.

Mandel, a former state treasurer, tweeted, “Watching this sham impeachment has made my blood boil and motivated me to run. I’m going to Washington to fight for President Trump’s America First Agenda.”

Mandel will likely face former Ohio GOP Chairwoman Jane Timken, who is expected to announce her bid for Senate at any time.

“She has a lot of work to do and so does Josh and the election starts now,” said Michael Gonidakis, an Ohio Republican strategist. “He’s battle tested and Jane is going to have to explain first time candidate, not running before and why she would be the better general election candidate.”

This will be Mandel’s third run for the U.S. Senate in Ohio. He lost to Senator Sherrod Brown in 2012. Mandel ran again in 2018 before suddenly stepping away from the election that Brown ultimately won again.

On Wednesday, Brown declined to react to the announcement.

“I don’t really have any interest in who is lining up to do the bidding of Donald Trump every minute, every hour of the day,” he said.

At least two Democrats, Ohio Congressman Tim Ryan and former state health director Dr. Amy Acton, are at least looking at running. Neither has officially announced.

“When it’s all said and done, look, anyone can run, anyone can file their petitions, but it’s going to be a two-person race on the Republican side and a two-person race on the Democrats side,” Gonidakis said.